Flow-mediated endothelial mechanotransduction
نویسندگان
چکیده
منابع مشابه
Flow-mediated endothelial mechanotransduction.
Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodeling, and the localization of atherosclerotic lesions. Major regulation of the blood vessel responses occurs by the action of hemodynamic shear stresses on the endothelium. The transmission of hemodynamic forces throughout the endothelium and th...
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In this inaugural paper, we shall provide an overview of the endothelial surface layer or glycocalyx in several roles: as a transport barrier, as a porous hydrodynamic interface in the motion of red and white cells in microvessels, and as a mechanotransducer of fluid shearing stresses to the actin cortical cytoskeleton of the endothelial cell. These functions will be examined from a new perspec...
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ژورنال
عنوان ژورنال: Physiological Reviews
سال: 1995
ISSN: 0031-9333,1522-1210
DOI: 10.1152/physrev.1995.75.3.519